Seaprose S vs. Serrapeptase: A Comparative Guide

Seaprose S (also called Protease S or Actinase) is a semi-alkaline enzyme, meaning it works well in a slightly basic pH environment such as the intestines. It is derived from a natural fungus called Aspergillus melleus and belongs to the proteolytic enzyme family because it breaks down proteins that can cause swelling and congestion.

Seaprose S is known for being:

• Anti-inflammatory: Helps calm the body’s response to injury or irritation.

   

• Anti-edematous: Reduces fluid buildup and swelling in tissues.

   

• Mucolytic: Thins and loosens thick mucus, especially in the lungs and sinuses.

   

These actions make Seaprose S helpful in managing conditions like chronic bronchitis, sinusitis, asthma, and post-surgical swelling.

At a biological level, Seaprose S works by reducing the activity of white blood cells (neutrophils) that can worsen inflammation. It also lowers the levels of inflammatory chemicals in the body, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) [1]. Additionally, it helps protect cells from oxidative stress, which is damage caused by unstable molecules (free radicals) that build up during chronic inflammation [2].

Importantly, Seaprose S is considered gentle on the stomach, making it well-suited for daily and long-term use.

Listen to the Great Wellness Reset Podcast Episode: The Enzyme Edge!

Serrapeptase, also known as Serratiopeptidase, is an enzyme originally found in the gut of silkworms, where it helps them dissolve their cocoons. It is now made through fermentation by a bacterium called Serratia marcescens. Like Seaprose S, it breaks down unwanted proteins in the body.

Serrapeptase is known for:

• Fibrinolytic properties: It breaks down fibrin, a protein involved in blood clotting and scar tissue formation.

• Anti-inflammatory action: Reduces swelling and tissue irritation.

• Analgesic effect: Helps reduce pain, especially when caused by inflammation.

This enzyme is commonly used for post-surgical recovery, arthritis, chronic sinus infections, and fibrocystic breast conditions.

Serrapeptase works by dissolving fibrin, which helps the body clear out clots, dead tissue, and excess fluids. It also helps regulate bradykinin and prostaglandins, which are chemicals involved in pain and inflammation [3].

However, Serrapeptase is known to sometimes cause digestive side effects, such as bloating, nausea, or gas, particularly when taken without food. Because of its ability to break down fibrin, it may not be suitable for people who are taking blood-thinning medications or have bleeding disorders.

 Both Seaprose S and Serrapeptase are effective systemic enzymes with important therapeutic roles. But for those seeking a gentle, well-rounded, and multi-purpose enzyme, Seaprose S is often the better choice. It delivers strong respiratory and anti-inflammatory benefits, supports immune balance, and has minimal side effects—making it ideal for everyday use.

That’s why Seaprose S is found in many broad-spectrum proteolytic enzyme supplements that also includes Nattokinase, Bromelain, Peptidase, Catalase, Rutin, and antioxidant support to promote total-body wellness, recovery, and inflammation management—naturally.

1. Inoue M, et al. Effect of Seaprose S on cytokine production and neutrophil accumulation in a murine model of inflammation. Inflammation Research.

2. Mazzone A, et al. Evaluation of Seaprose S on oxidative stress markers in patients with chronic sinusitis. Clin Ter.

3. Esch PM, et al. Serrapeptase: An orally available anti-inflammatory agent. Journal of International Medical Research.
   
4. Yamamoto Y, et al. Efficacy of Seaprose S in reducing sputum viscosity in chronic bronchitis. Respir Med. 1997.